Lycorine Hydrochloride
Lycorine hydrochloride fari ne zuwa fari-fari foda wanda aka samo daga alkaloid lycorine, wanda ke samuwa a cikin tsire-tsire na Lycoris radiata (L'Her.), kuma yana cikin dangin Amaryllidaceae. Lycorine hydrochloride yana da tasiri daban-daban na magunguna, ciki har da anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, da anti-malaria Properties. Yana narkewa a cikin ruwa, DMSO, da ethanol. Tsarin sinadarai yana da siffa mai rikitarwa ta tsarin steroidal tare da ɗanɗano mai ɗaci tare da ƙungiyoyi masu aiki da yawa, gami da hydroxyl da ƙungiyoyin amino, suna ba da gudummawa ga ayyukan ilimin halitta.
| Sunan samfur | Lycorine hydrochloride CAS: 2188-68-3 | ||
| Tushen Shuka | Lycoris | ||
| Yanayin ajiya | Ajiye tare da hatimi a zafin jiki | Kwanan rahoton | 2024.08.24 |
| Abu | Daidaitawa | Sakamako |
| Tsafta(HPLC) | Lycorine hydrochloride≥98% | 99.7% |
| Bayyanar | Kashe-farar foda | Ya dace |
| Halin jikiics | ||
| Girman barbashi | NLT100% 80raga | Ya dace |
| Asarar bushewa | ≤1.0% | 1.8% |
| Mai nauyi karfe | ||
| Jimlar karafa | ≤10.0pm | Ya dace |
| Jagoranci | ≤2.0pm | Ya dace |
| Mercury | ≤1.0pm | Ya dace |
| Cadmium | ≤0.5pm | Ya dace |
| Microorganism | ||
| Jimlar adadin ƙwayoyin cuta | ≤1000cfu/g | Ya dace |
| Yisti | ≤100cfu/g | Ya dace |
| Escherichia coli | Ba a haɗa ba | Ba a gano ba |
| Salmonella | Ba a haɗa ba | Ba a gano ba |
| Staphylococcus | Ba a haɗa ba | Ba a gano ba |
| Ƙarshe | Cancanta | |
Siffofin:
(1) Tsabta Mai Girma:Ana sarrafa samfuranmu da kyau don tabbatar da babban matakin tsabta, wanda ke da mahimmanci don tasiri da aminci a aikace-aikace daban-daban.
(2) Abubuwan Magance Cutar Daji:Ya nuna mahimmancin tasirin maganin ciwon daji akan nau'in ciwon daji iri-iri, duka a cikin vitro da a cikin vivo, ta hanyar hanyoyin da suka haɗa da haifar da kamawar kwayar halitta, haifar da apoptosis, da hana angiogenesis.
(3) Aiki Maɗaukaki:An yi imanin Lycorine hydrochloride yana yin hulɗa tare da maƙasudin ƙwayoyin ƙwayoyin cuta, yana ba da tasiri mai fa'ida akan ƙwayoyin cutar kansa.
(4) Rashin Guba:Yana nuna ƙarancin guba ga sel na al'ada, wanda shine muhimmin mahimmanci a cikin yuwuwar amfani da shi azaman wakili na warkewa.
(5) Fayil na Pharmacokinetic:An yi nazarin samfurin don magungunan ƙwayoyi, yana nuna saurin sha da kuma kawar da sauri daga plasma, wanda ke da mahimmanci don yin allurai da tsarin farfadowa.
(6) Tasirin Haɗin Kai:Lycorine hydrochloride ya nuna ingantaccen sakamako idan aka yi amfani da shi tare da wasu magunguna, wanda zai iya zama da amfani wajen shawo kan juriya na miyagun ƙwayoyi da inganta sakamakon magani.
(7) Bincike-Bayani:Samfurin yana tallafawa ta hanyar bincike mai zurfi, yana ba da tushe mai ƙarfi don amfani da shi a cikin haɓakar magunguna da aikace-aikacen asibiti.
(8) Tabbacin inganci:Ana aiwatar da matakan kula da ingancin inganci a duk lokacin aikin samarwa don tabbatar da daidaito da amincin samfurin.
(9) Aikace-aikace iri-iri:Ya dace don amfani a cikin bincike da haɓakawa don aikace-aikacen magunguna, gami da gano magunguna da haɓakar cututtukan daji.
(10) Biyayya:Kerarre ta bin ka'idodin GMP don tabbatar da amincin samfurin da ingancinsa.
(1) Masana'antar harhada magunguna:Ana amfani da Lycorine hydrochloride a cikin haɓaka magungunan ƙwayoyin cuta da ƙwayoyin cuta.
(2) Masana'antar Biotechnology:Ana amfani da shi a cikin bincike da haɓaka sababbin magungunan warkewa da magungunan ƙwayoyi.
(3) Binciken samfuran halitta:Ana nazarin Lycorine hydrochloride don yuwuwar fa'idodin lafiyar sa da kaddarorin magani.
(4) Masana'antar sinadarai:Ana iya amfani da shi azaman tsaka-tsakin sinadarai a cikin haɗin wasu mahadi.
(5) Masana'antar Noma:An bincika Lycorine hydrochloride don yuwuwar sa a matsayin maganin kashe kwari na halitta da mai kula da ci gaban shuka.
Tsarin hakar lycorine hydrochloride yawanci ya haɗa da mahimman matakai masu zuwa don tabbatar da tsabtar sauran ƙarfi da haɓaka ƙimar farfadowa:
(1) Zaɓin ɗanyen abu da riga-kafi:Zaɓi albarkatun shuka da suka dace na Amaryllidaceae, kamar kwararan fitila na Amaryllis, a wanke, bushe da murkushe su don tabbatar da tsabtar albarkatun ƙasa da aza harsashin hakar na gaba.
(2)Haɗin enzyme pretreatment:Yi amfani da hadaddun enzymes (kamar cellulase da pectinase) don tsara kayan da aka murkushe don ruguza ganuwar tantanin halitta da inganta haɓakar haɓakawa na gaba.
(3)Tsarkake leaching hydrochloric acid:A haxa kayan da aka riga aka gyara tare da tsarma ruwa hydrochloric acid don cire lycorine. Yin amfani da acid hydrochloric yana taimakawa wajen ƙara yawan solubility na lycorine, don haka inganta haɓakar haɓaka.
(4)Ultrasonic-taimaka hakar:Amfani da ultrasonic-taimaka hakar fasahar iya hanzarta narkar da tsari na lycorine a cikin sauran ƙarfi da kuma inganta hakar yadda ya dace da kuma tsarki.
(5)Hakar Chloroform:Ana yin hakar tare da abubuwan kaushi na halitta kamar chloroform, kuma ana canja wurin lycorine daga yanayin ruwa zuwa tsarin kwayoyin halitta don ƙara tsarkake mahaɗin da ake nufi.
(6)Mai da narkewa:Bayan aikin hakar, ana dawo da sauran ƙarfi ta hanyar ƙashin ruwa ko distillation don rage yawan amfani da ƙarfi da haɓaka tattalin arziki.
(7)Tsarkakewa da bushewa:Ta hanyar tsarkakewa da matakan bushewa masu dacewa, ana samun foda mai tsabta na lycorine hydrochloride.
A cikin dukkan tsarin hakar, sarrafa zaɓin sauran ƙarfi, yanayin hakar (kamar ƙimar pH, zafin jiki, da lokaci), da matakan tsarkakewa na gaba shine mabuɗin don tabbatar da tsaftataccen ƙarfi da haɓaka ƙimar dawowa. Yin amfani da kayan aikin hakar zamani da kayan aikin tsarkakewa, irin su ultrasonic extractors da high-performance liquid chromatography (HPLC) tsarin, kuma taimaka inganta hakar yadda ya dace da samfurin ingancin.
Adana: Ajiye a wuri mai sanyi, bushe, da tsabta, Kariya daga danshi da haske kai tsaye.
Kunshin girma: 25kg/drum.
Lokacin Jagora: kwanaki 7 bayan odar ku.
Shelf Life: 2 shekaru.
Lura: Hakanan ana iya samun takamaiman ƙayyadaddun bayanai.
Bayyana
A karkashin 100kg, 3-5days
Sabis ɗin ƙofa zuwa kofa cikin sauƙin ɗaukar kaya
Ta Teku
Sama da 300kg, Kusan Kwana 30
Ana buƙatar ƙwararrun dillalan share fage na sabis na tashar jiragen ruwa zuwa tashar jiragen ruwa
By Air
100kg-1000kg, 5-7 Kwanaki
Filin jirgin sama zuwa sabis na filin jirgin sama ana buƙatar dillalan ƙwararrun ƙwararru
Bioway Organic ya sami USDA da EU Organic, BRC, ISO, HALAL, KOSHER, da takaddun HACCP.
Lycorine alkaloids ne na halitta wanda ke faruwa a cikin tsire-tsire da yawa, musamman a cikin dangin Amaryllidaceae. Ga wasu tsire-tsire da aka sani suna ɗauke da lycorine:
Lycoris radiata(wanda aka fi sani da jan gizo-gizo Lily ko manjushage) ganyen magani ne na gargajiyar kasar Sin wanda ke dauke da sinadarin lycorine.
Leucojum aestuum(Dusar ƙanƙara na lokacin rani), kuma an san yana ɗauke da lycorine.
Ungernia sewertzowiiwani tsiro ne daga dangin Amaryllidaceae wanda aka ruwaito yana dauke da lycorine.
Hippeastrum Hybrid (Lily Easter)da sauran tsire-tsire na Amaryllidaceae sanannun tushen lycorine.
Wadannan tsire-tsire suna yadu a yankuna masu zafi da na wurare masu zafi a duniya kuma suna da tarihin amfani da su a cikin maganin gargajiya. Kasancewar lycorine a cikin waɗannan tsire-tsire ya kasance batun bincike saboda yuwuwar abubuwan da ke tattare da magunguna, gami da tasirin maganin cutar kansa kamar yadda aka nuna a cikin bincike daban-daban.
Lycorine shine alkaloid na halitta tare da nau'ikan tasirin magunguna, gami da yuwuwar amfani da shi wajen maganin ciwon daji. Yayin da ya nuna sakamako mai ban sha'awa a cikin bincike daban-daban, akwai wasu sakamako masu illa da la'akari da amfani da shi:
Ƙananan Guba: Lycorine da gishirin hydrochloride gabaɗaya suna nuna ƙarancin guba, wanda shine kyakkyawan yanayin aikace-aikacen asibiti. An nuna cewa yana da ƙananan sakamako masu illa akan ƙwayoyin ɗan adam na al'ada da kuma beraye masu lafiya, suna nuna wani matakin zaɓi don ƙwayoyin ciwon daji akan kyallen takarda na al'ada.
Tasirin Sauye-sauye: An lura da tashin zuciya da amai na wucin gadi biyo bayan allurar lycorine hydrochloride na subcutaneous ko ta jijiya, yawanci tana raguwa cikin sa'o'i 2.5 ba tare da shafar lafiyar sinadarai ko lafiyar jini ba.
Babu wani aiki mai saurin sarrafawa: Karatun ya nuna cewa serial allurai na Lycorine ba su shafi tsarin da juyayi mai zurfi (CNS) sakamako mai zurfi da suka shafi ikon sarrafa motoci.
Tasiri akan Ayyukan Locomotor na Kwatsam: A kashi na 30 mg / kg, an lura da lycorine don lalata ayyukan locomotor na gaggawa a cikin mice, kamar yadda aka nuna ta hanyar raguwar halayen reno da karuwa a cikin rashin motsi.
Halayen Gabaɗaya da Lafiya: Wani nau'in 10 mg / kg na lycorine bai lalata halaye na gabaɗaya da jin daɗin berayen ba, yana nuna cewa wannan zai iya zama mafi kyawun kashi don kimanta ingancin warkewa na gaba.
Babu Muhimman Tasirin Mummuna akan Nauyin Jiki ko Matsayin Lafiya: Gudanar da lycorine da lycorine hydrochloride ba su haifar da sakamako mai ban mamaki ba akan nauyin jiki ko matsayin lafiyar gaba ɗaya a cikin ƙirar linzamin kwamfuta mai ɗauke da ƙari.
Yana da mahimmanci a lura cewa yayin da lycorine ya nuna yuwuwar a cikin binciken bincike na yau da kullun, ƙimar ƙimar guba na dogon lokaci har yanzu ba a samu ba. Ana buƙatar ƙarin bincike don cikakken fahimtar bayanin martabarsa, musamman don amfani na dogon lokaci kuma a cikin saitunan asibiti. Abubuwan illa da amincin lycorine na iya bambanta dangane da sashi, hanyar gudanarwa, da halaye na mutum ɗaya. Koyaushe tuntuɓi ƙwararren kiwon lafiya kafin yin la'akari da amfani da kowane sabon kari ko magani.
