Lycorine Hydrochloride
Lycorine hydrochloride foda ne da aka samo daga alkaloid lycorine, wanda ake samu a cikin tsire-tsire na Lycoris radiata (L'Her.), kuma yana cikin dangin Amaryllidaceae. Lycorine hydrochloride yana da tasirin magunguna daban-daban, ciki har da maganin ƙari, maganin ciwon daji, maganin HCV, maganin kumburi, maganin ƙwayoyin cuta, maganin ƙwayoyin cuta, maganin angiogenesis, da kuma maganin zazzabin cizon sauro. Yana narkewa a cikin ruwa, DMSO2, da ethanol. Tsarin sinadaransa yana da alaƙa da tsarin steroid mai rikitarwa tare da ɗanɗano mai ɗaci tare da ƙungiyoyi masu aiki da yawa, gami da ƙungiyoyin hydroxyl da amino, suna ba da gudummawa ga ayyukan halittu.
| Sunan samfurin | Lycorine hydrochloride CAS:2188-68-3 | ||
| Tushen Shuke-shuke | Lycoris | ||
| Yanayin Ajiya | A adana da hatimi a zafin ɗaki | Ranar Rahoton | 2024.08.24 |
| Abu | Daidaitacce | Sakamako |
| Tsarkaka(HPLC） | Lycorine hydrochloride≥98% | 99.7% |
| Bayyanar | Foda mai launin fari | Ya dace |
| Halin jikiics | ||
| Girman ƙwayar cuta | NLT100% 80Rata | Ya dace |
| Asara idan aka busar da ita | ≤1.0% | 1.8% |
| Mai nauyi ƙarfe | ||
| Jimlar karafa | ≤10.0ppm | Ya dace |
| Jagora | ≤2.0ppm | Ya dace |
| Mercury | ≤1.0ppm | Ya dace |
| Cadmium | ≤0.5ppm | Ya dace |
| Ƙananan halittu | ||
| Jimlar adadin ƙwayoyin cuta | ≤1000cfu/g | Ya dace |
| Yis | ≤100cfu/g | Ya dace |
| Escherichia coli | Ba a haɗa ba | Ba a gano ba |
| Salmonella | Ba a haɗa ba | Ba a gano ba |
| Staphylococcus | Ba a haɗa ba | Ba a gano ba |
| Kammalawa | Wanda ya cancanta | |
Siffofi:
(1) Tsarkakakken Tsafta:Ana sarrafa samfurinmu sosai don tabbatar da tsafta mai yawa, wanda yake da mahimmanci don inganci da aminci a aikace-aikace daban-daban.
(2) Ka'idojin hana ciwon daji:Ya nuna tasirin da ke da matuƙar muhimmanci wajen yaƙi da nau'ikan ciwon daji iri-iri, a cikin jiki da kuma a cikin jiki, ta hanyar hanyoyin da suka haɗa da haifar da kamawar zagayowar ƙwayoyin halitta, haifar da apoptosis, da kuma hana angiogenesis.
(3) Aiki Mai Niyya Da Yawa:Ana kyautata zaton Lycorine hydrochloride yana hulɗa da maƙasudai daban-daban na kwayoyin halitta, yana ba da tasiri mai faɗi akan ƙwayoyin cutar kansa.
(4) Ƙarancin Guba:Yana nuna ƙarancin guba ga ƙwayoyin halitta na yau da kullun, wanda shine muhimmin abu a cikin yuwuwar amfani da shi azaman maganin warkewa.
(5) Bayanin Magungunan Magani:An yi nazarin samfurin don maganin pharmacokinetics, yana nuna shansa cikin sauri da kuma kawar da shi cikin sauri daga cikin plasma, wanda yake da mahimmanci don allurai da tsara magani.
(6) Tasirin Haɗin gwiwa:Lycorine hydrochloride ya nuna ingantaccen tasiri idan aka yi amfani da shi tare da wasu magunguna, wanda zai iya zama da amfani wajen shawo kan juriyar magunguna da inganta sakamakon magani.
(7) Bincike Ya Tabbatar:Ana samun tallafin wannan samfurin ta hanyar bincike mai zurfi, wanda ke samar da tushe mai ƙarfi don amfani da shi a cikin haɓaka magunguna da aikace-aikacen asibiti.
(8) Tabbatar da Inganci:Ana aiwatar da tsauraran matakan kula da inganci a duk lokacin aikin samarwa don tabbatar da daidaito da amincin samfurin.
(9) Aikace-aikace iri-iri:Ya dace da amfani a bincike da haɓaka aikace-aikacen magunguna, gami da gano magunguna da haɓaka maganin ciwon daji.
(10) Bin ƙa'idodi:An ƙera shi bisa ga ƙa'idodin GMP don tabbatar da aminci da ingancin samfurin.
(1) Masana'antar harhada magunguna:Ana amfani da Lycorine hydrochloride wajen samar da magungunan kashe ƙwayoyin cuta da kuma maganin ciwon daji.
(2) Masana'antar fasahar kere-kere:Ana amfani da shi wajen bincike da haɓaka sabbin magungunan warkarwa da kuma hanyoyin magani.
(3) Binciken samfuran halitta:Ana nazarin Lycorine hydrochloride don fa'idodin da ke tattare da shi ga lafiya da kuma kaddarorin magani.
(4) Masana'antar sinadarai:Ana iya amfani da shi a matsayin matsakaiciyar sinadarai wajen haɗa wasu mahadi.
(5) Masana'antar noma:An binciki Lycorine hydrochloride saboda yuwuwar sa a matsayin maganin kashe kwari na halitta da kuma mai daidaita ci gaban tsirrai.
Tsarin cire lycorine hydrochloride yawanci ya haɗa da waɗannan mahimman matakai don tabbatar da tsarkin sinadarin da kuma inganta saurin murmurewa:
(1) Zaɓin kayan da aka sarrafa kafin a fara amfani da su:Zaɓi kayan albarkatun ƙasa na shukar Amaryllidaceae da suka dace, kamar kwararan fitilar Amaryllis, sannan a wanke, a busar da su sannan a niƙa su don tabbatar da tsarkin kayan da aka girbe sannan a shimfiɗa harsashin don cirewa daga baya.
(2)Haɗaɗɗen enzyme kafin a fara magani:Yi amfani da hadaddun enzymes (kamar cellulase da pectinase) don magance kayan da aka niƙa kafin a lalata su don ruguza bangon ƙwayoyin shuka da kuma inganta ingancin cirewa daga baya.
(3)Rage sinadarin hydrochloric acid ta hanyar narkewa:A haɗa kayan da aka riga aka yi wa magani da ruwan hydrochloric acid mai narkewa don cire lycorine. Amfani da hydrochloric acid yana taimakawa wajen ƙara narkewar lycorine, ta haka ne inganta ingancin fitar da shi.
(4)Fitar da aka taimaka wa ultrasonic:Amfani da fasahar cirewa ta hanyar amfani da ultrasonic zai iya hanzarta tsarin narkewar lycorine a cikin ruwan da ke narkewa da kuma inganta ingancin cirewa da tsarki.
(5)Cire Chloroform:Ana cire sinadarin ta hanyar amfani da sinadarai masu narkewa kamar chloroform, kuma ana canza sinadarin lycorine daga matakin ruwa zuwa matakin kwayoyin halitta domin kara tsarkake sinadarin da ake bukata.
(6)Maido da sinadarin da ke narkewa:Bayan an cire sinadarin, ana samun sinadarin ta hanyar fitar da shi daga jiki ko kuma fitar da shi daga jiki domin rage yawan sinadarin da ke cikinsa da kuma inganta tattalin arzikinsa.
(7)Tsarkakewa da busarwa:Ta hanyar matakan tsarkakewa da bushewa masu dacewa, ana samun foda lycorine hydrochloride mai tsarki.
A duk tsawon tsarin cirewa, sarrafa zaɓin sinadaran, yanayin cirewa (kamar ƙimar pH, zafin jiki, da lokaci), da kuma matakan tsarkakewa na gaba sune mabuɗin tabbatar da tsarkin sinadaran da kuma inganta saurin murmurewa. Amfani da kayan aikin cirewa da tsarkakewa na zamani, kamar masu cirewa da ultrasonic da tsarin chromatography na ruwa mai ƙarfi (HPLC), suma suna taimakawa wajen inganta ingancin cirewa da ingancin samfura.
Ajiya: A ajiye a wuri mai sanyi, bushe, kuma mai tsabta. A kare shi daga danshi da haske kai tsaye.
Kunshin Girma: 25kg/ganga.
Lokacin Gabatarwa: Kwanaki 7 bayan odar ku.
Rayuwar Shiryayye: Shekaru 2.
Bayani: Hakanan ana iya cimma takamaiman ƙayyadaddun bayanai.
Express
Ƙasa da 100kg, Kwanaki 3-5
Sabis na ƙofa zuwa ƙofa mai sauƙin ɗaukar kaya
Ta Teku
Fiye da 300kg, Kimanin kwanaki 30
Ana buƙatar dillalin kwararru na aikin tashar jiragen ruwa zuwa tashar jiragen ruwa
Ta hanyar Jirgin Sama
100kg-1000kg, Kwanaki 5-7
Ana buƙatar dillalin lasisin ƙwararru daga filin jirgin sama zuwa filin jirgin sama
Bioway Organic ta sami takaddun shaida na USDA da EU na halitta, BRC, ISO, HALAL, KOSHER, da HACCP.
Lycorine wani alkaloid ne da ake samu a yanayi daban-daban wanda ake samu a cikin tsirrai da dama, musamman a cikin dangin Amaryllidaceae. Ga wasu tsire-tsire da aka sani suna ɗauke da lycorine:
Lycoris radiata(wanda kuma aka sani da jan gizo-gizo lily ko manjushage) wata ganye ce ta gargajiya ta kasar Sin wadda ke dauke da sinadarin lycorine.
Leucojum aestivum(dusar ƙanƙara ta bazara), an kuma san ta da ƙunshe da lycorine.
Ungernia sewertzowiiwani shuka ne daga dangin Amaryllidaceae wanda aka ruwaito yana ɗauke da lycorine.
Hippeastrum hybrid (Lily na Easter)da sauran shuke-shuken Amaryllidaceae da suka shafi su sanannu ne tushen lycorine.
Waɗannan tsire-tsire suna yaɗuwa sosai a yankuna masu zafi da kuma yankunan da ke ƙarƙashin zafi a duniya kuma suna da dogon tarihi na amfani da su a maganin gargajiya. Kasancewar lycorine a cikin waɗannan tsire-tsire ya zama batun bincike saboda yuwuwar kaddarorin magunguna, gami da tasirinsa mai mahimmanci na maganin ciwon daji kamar yadda aka nuna a cikin bincike daban-daban.
Lycorine wani sinadari ne na halitta wanda ke da nau'ikan tasirin magunguna iri-iri, gami da yuwuwar amfani da shi a cikin maganin cutar kansa. Duk da cewa ya nuna sakamako mai kyau a cikin bincike daban-daban, akwai wasu illoli da aka ruwaito da suka shafi amfani da shi:
Ƙarancin Guba: Lycorine da gishirin hydrochloride gabaɗaya suna nuna ƙarancin guba, wanda hakan yana da kyau ga aikace-aikacen asibiti. An nuna cewa yana da ƙarancin illa ga ƙwayoyin halittar ɗan adam na yau da kullun da beraye masu lafiya, wanda ke nuna wani matakin zaɓi ga ƙwayoyin cutar kansa fiye da kyallen halitta na yau da kullun.
Tasirin Kwayar Cutar da ke Canzawa: An lura da tashin zuciya da amai na ɗan lokaci bayan allurar lycorine hydrochloride ta ƙarƙashin ƙasa ko ta jijiya, yawanci tana raguwa cikin awanni 2.5 ba tare da shafar lafiyar sinadarai ko lafiyar jini ba.
Babu Daidaito a Motsa Jiki: Bincike ya nuna cewa allurai na lycorine ba sa shafar daidaiton motsi a cikin beraye, kamar yadda gwajin rotarod ya gwada, yana nuna cewa ba ya haifar da illa ga tsarin jijiyoyi na tsakiya (CNS) da ke da alaƙa da sarrafa motsi.
Tasirin Aikin Motsa Jiki Ba Tare Da Tafiya Ba: A wani allurar 30 mg/kg, an lura cewa lycorine yana rage aikin motsa jiki ba tare da wata matsala ba a cikin beraye, kamar yadda aka nuna ta hanyar raguwar halayen renon yara da kuma ƙaruwar rashin motsi.
Halayya da Jin Daɗin Jiki Gabaɗaya: Shan maganin lycorine na 10 mg/kg bai shafi halayen beraye da walwalarsu ba, yana nuna cewa wannan zai iya zama mafi kyawun allurar don kimanta ingancin magani a nan gaba.
Babu Mummunan Tasiri Kan Nauyin Jiki Ko Halin Lafiya: Shan lycorine da lycorine hydrochloride bai haifar da illa ga lafiyar jiki ko yanayin lafiyar gaba ɗaya ba a cikin samfuran beraye masu ɗauke da ƙari.
Yana da mahimmanci a lura cewa duk da cewa lycorine ya nuna yuwuwar a cikin binciken asibiti kafin a fara amfani da shi, har yanzu ba a sami kimantawar guba ta dogon lokaci ba. Ana buƙatar ƙarin bincike don fahimtar cikakken bayanin lafiyarsa, musamman don amfani na dogon lokaci da kuma a wuraren asibiti. Illolin da amincin lycorine na iya bambanta dangane da yawan da ake amfani da shi, hanyar da ake amfani da shi, da halayen kowane majiyyaci. Koyaushe a tuntuɓi ƙwararren likita kafin a yi la'akari da amfani da kowane sabon kari ko magani.
