Foda Mai Tsarki ta Rotundine (l-tetrahydropalmatine，l-THP)

Rotundine, wanda aka fi sani da l-tetrahydropalmatine (l-THP), wani sinadari ne mai tasirin magunguna wanda ke shafar tsarin jijiyoyi na tsakiya da tsarin zuciya da jijiyoyin jini. An ruwaito cewa yana da tasirin rage zafi, kwantar da hankali, hypnotic, da kuma anxiolytic. Bugu da ƙari, an nuna cewa yana da tasirin kariya akan raunin ischemia-reperfusion na kwakwalwa da zuciya. An kuma san Rotundine saboda yuwuwarsa ta mayar da martani ga juriyar magunguna da yawa a cikin ƙwayoyin cutar kansa da kuma halayen toshe hanyoyin calcium.
Ana iya samunsa daga tubers na Stephania tetrandra da Corydalis yanhusuo, ko kuma ta hanyar haɗa sinadarai. An haɗa shi daga tetrahydropalmatine ta hanyar ragewa, yankewa, da kuma halayen alkalization. Ana iya samar da tetrahydropalmatine mai sinadarin iodine daga tetrahydropalmatine ta hanyar alkalization da oxidation don sake maimaitawa.
Ga magungunan pharmacokinetics, Rotundine yana sha sosai bayan an sha ta baki kuma galibi yana yaɗuwa a cikin kyallen mai kitse, sannan sai huhu, hanta, da koda. Yawanci ana fitar da shi ta cikin kodan. Nazarin da aka yi a kan beraye da zomaye ya nuna cewa Rotundine na iya shiga shingen jini da kwakwalwa ya shiga cikin kyallen kwakwalwa, tare da yawan kwakwalwa ƙasa da yawan jini bayan awanni 2.
Don mummunan sakamako, Rotundine na iya haifar da barci, jiri, gajiya, tashin zuciya, da kuma wani lokacin girgizar rashin lafiyan. Gargaɗi sun haɗa da guje wa amfani da shi ga mata masu juna biyu da masu shayarwa, sanin yuwuwar jurewa amfani da shi na dogon lokaci, da kuma yin taka tsantsan lokacin shan magungunan rage damuwa na tsarin jijiyoyi tare, tare da daidaita yawan shan magani idan ya cancanta.
A taƙaice, Rotundine wani sinadari ne mai tasirin magunguna daban-daban, kuma kaddarorinsa sun sa ya zama abin sha'awa a cikin bincike daban-daban, ciki har da maganin ciwo, lafiyar zuciya da jijiyoyin jini, da kuma maganin ciwon daji. Don ƙarin bayani tuntuɓi.grace@biowaycn.com.